HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 90203741, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-(5-Methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amine | HCID 90203430 | — |
| Reactant | 5-Cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid | HCID 90204044 | — |
| Product | HCID 90203741 | HCID 90203741 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid (enantiomer B) (example 289b) and 2-(5-methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amine;hydrobromide (enantiomer A) (example 124b) as starting materials and isolated (52.5 mg, 71%); MS (ESI, m/z): 441.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-adbe9ba5172841eca8cefca6ed506bdb |
| Source note | uspto-grants-2016_08 |