Hydrogen Bromide → HCID 90203741, compound

HRID 1480352Notes

Reaction equation

HRID 1480352 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH:14]([CH3:17])[CH2:15][F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:18][C:19]1[O:23][N:22]=[C:21]([C:24]([NH2:31])([CH3:30])[CH2:25][S:26]([CH3:29])(=[O:28])=[O:27])[N:20]=1.Br>>[CH:1]1([C:4]2[C:5]([O:13][CH:14]([CH3:17])[CH2:15][F:16])=[CH:6][C:7]([C:10]([NH:31][C:24]([C:21]3[N:20]=[C:19]([CH3:18])[O:23][N:22]=3)([CH3:30])[CH2:25][S:26]([CH3:29])(=[O:28])=[O:27])=[O:12])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 902034302-(5-Methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amineHCID 902040445-Cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid

Product 1

HCID 90203741HCID 90203741, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid (enantiomer B) (example 289b) and 2-(5-methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amine;hydrobromide (enantiomer A) (example 124b) as starting materials and isolated (52.5 mg, 71%); MS (ESI, m/z): 441.4 (M+H+).

Workup

  1. customisolated (52.5 mg, 71%)

Sources & evidence

ORD record
ord-adbe9ba5172841eca8cefca6ed506bdb
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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