Sodium hydride → HCID 90215000, compound

HRID 1480356Notes

Reaction equation

HRID 1480356 reaction equation
Cl[C:2]1[C:7]([C:8]2([F:12])[CH2:11][CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:13]#[N:14])[CH:3]=1.[F:15][C:16]([F:21])([F:20])[C@@H:17]([OH:19])[CH3:18].[H-].[Na+]>>[F:12][C:8]1([C:7]2[C:2]([O:19][C@@H:17]([CH3:18])[C:16]([F:21])([F:20])[F:15])=[CH:3][C:4]([C:13]#[N:14])=[N:5][CH:6]=2)[CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 6999971(2S)-1,1,1-Trifluoropropan-2-olHCID 90204016HCID 90204016, compound

Product 1

HCID 90215000HCID 90215000, compound

Procedure

The title compound was synthesized in analogy to Example 123c, using 4-chloro-5-(1-fluorocyclobutyl)-pyridine-2-carbonitrile (example 305c) and (S)-1,1,1-Trifluoro-propan-2-ol (CAN 3539-97-7) as starting materials and sodium hydride as reagent. The title was isolated (1.23 g, 90%) as a yellow oil; MS (ESI, m/z): 289.2 (M+H+).

Workup

  1. customThe title was isolated (1.23 g, 90%) as a yellow oil

Sources & evidence

ORD record
ord-7c7d098e4f9e4eecb900ac44bca04ef3
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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