Sodium hydride → HCID 90203483, compound

HRID 1480360Notes

Reaction equation

HRID 1480360 reaction equation
Cl[C:2]1[C:7]([C:8]2([F:12])[CH2:11][CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:13]#[N:14])[CH:3]=1.[F:15][CH:16]([F:19])[CH2:17][OH:18].[H-].[Na+]>>[F:15][CH:16]([F:19])[CH2:17][O:18][C:2]1[C:7]([C:8]2([F:12])[CH2:11][CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:13]#[N:14])[CH:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 1361872,2-Difluoroethan-1-olHCID 90204016HCID 90204016, compound

Product 1

HCID 90203483HCID 90203483, compound

Procedure

The title compound was synthesized in analogy to Example 123c, using 4-chloro-5-(1-fluorocyclobutyl)-pyridine-2-carbonitrile (example 305c) and 2,2-Difluoro-ethanol (CAN 359-13-7) as starting materials and sodium hydride as reagent. The title was isolated (1 g, 83%) as a yellow oil; MS (ESI, m/z): 257.1 (M+H+).

Workup

  1. customThe title was isolated (1 g, 83%) as a yellow oil

Sources & evidence

ORD record
ord-295e66b913ca4799a9e37d1211ce419e
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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