2-Oxo-5-methyl-4-oxazoline-4-carboxylic acid → 3,5-Dichlorobenzyl 4-(2-(N,5-dimethyl-2-oxo-2,3-dihydrooxazole-4-carboxamido)ethyl)piperidine-1-carboxylate

HRID 1480375Notes

Reaction equation

HRID 1480375 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([Cl:22])[CH:16]=2)=[O:12])[CH2:7][CH2:6]1.[CH3:23][C:24]1[O:28][C:27](=[O:29])[NH:26][C:25]=1[C:30](O)=[O:31]>>[CH3:1][N:2]([CH2:3][CH2:4][CH:5]1[CH2:6][CH2:7][N:8]([C:11]([O:13][CH2:14][C:15]2[CH:16]=[C:17]([Cl:22])[CH:18]=[C:19]([Cl:21])[CH:20]=2)=[O:12])[CH2:9][CH2:10]1)[C:30]([C:25]1[NH:26][C:27](=[O:29])[O:28][C:24]=1[CH3:23])=[O:31]

Participants

3

Reactant 2

HCID 537092082-Oxo-5-methyl-4-oxazoline-4-carboxylic acidHCID 86722625HCID 86722625, compound

Product 1

HCID 867226313,5-Dichlorobenzyl 4-(2-(N,5-dimethyl-2-oxo-2,3-dihydrooxazole-4-carboxamido)ethyl)piperidine-1-carboxylate

Procedure

The title compound was prepared from 3,5-dichlorobenzyl 4-(2-methylamino)ethyl)piperidine-1-carboxylate (Example 1, step 3) and 5-methyl-2-oxo-2,3-dihydrooxazole-4-carboxylic acid analogously to Example 6;

Sources & evidence

ORD record
ord-4b0067e3e7eb4b6ca9ac9bceb7130567
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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