Hydrochloric Acid → 3,5-Dichlorobenzyl 4-(methylamino)piperidine-1-carboxylate

HRID 1480397Notes

Reaction equation

HRID 1480397 reaction equation
C(O[C:6]([N:8](C)[CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([Cl:26])[CH:20]=2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[CH3:6][NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:20]=[C:21]([Cl:26])[CH:22]=[C:23]([Cl:25])[CH:24]=2)=[O:16])[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 867226393,5-Dichlorobenzyl 4-((tert-butoxycarbonyl)(methyl)amino)piperidine-1-carboxylate

Product 1

HCID 867226403,5-Dichlorobenzyl 4-(methylamino)piperidine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,5-Dichlorobenzyl 4-((tert-butoxycarbonyl)(methyl)amino)piperidine-1-carboxylate (2.4 g, 5.75 mmol) in DCM (13 ml) was treated with and 4M HCl in dioxane (14.38 ml, 57.5 mmol) to give a colourless solution. The mixture was stirred for 3.5 hours at room temperature and then concentrated under reduced pressure to afford the title compound which was used without further purification;

Workup

  1. customto give a colourless solution
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-17744ab0d3cb4ee4878b8826e58f4fda
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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