Methane → HCID 178525362, compound

HRID 1480400Notes

Reaction equation

HRID 1480400 reaction equation
C([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[N:10]=[N:9]1)C1C=CC=CC=1.C>CCO>[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[N:10]=[N:9]1

Participants

4

Reactant 2

HCID 297MethaneHCID 247519593-(1-Benzyl-1H-1,2,3-triazol-4-yl)propanoic acid

Product 1

HCID 178525362HCID 178525362, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(1-Benzyl-1H-1,2,3-triazol-4-yl)propanoic acid (step 1) (4.37 g, 18.90 mmol) was dissolved in EtOH and stirred for 10 mins with activated charcoal (1.13 g) and of Celite® (filter material). The reaction mixture was filtered and transferred into a 400 mL Duran Bottle. The colorless solution was set on a continuous cycle at 30 bar pressure and 70° C. through the H-Cube (continuous flow hydrogenation) for 24 hrs. The resulting material was concentrated under reduced pressure and the crude product was suspended in ether and filtered to afford the title compound;

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationThe resulting material was concentrated under reduced pressure
  3. filtrationfiltered

Sources & evidence

ORD record
ord-81d1f8268fd8447891891e03efa4ded0
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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