tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate → Tert-butyl 4-(2-(2-oxo-2,3-dihydrooxazole-5-carboxamido)ethyl)piperidine-1-carboxylate

HRID 1480406Notes

Reaction equation

HRID 1480406 reaction equation
[O:1]=[C:2]1[NH:6][CH:5]=[C:4]([C:7]([OH:9])=O)[O:3]1.[NH2:10][CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:14]1>>[O:1]=[C:2]1[NH:6][CH:5]=[C:4]([C:7]([NH:10][CH2:11][CH2:12][CH:13]2[CH2:14][CH2:15][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:17][CH2:18]2)=[O:9])[O:3]1

Participants

3

Reactant 2

HCID 1514258tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylateHCID 539814232-Hydroxy-1,3-oxazole-5-carboxylic acid

Product 1

HCID 86722643Tert-butyl 4-(2-(2-oxo-2,3-dihydrooxazole-5-carboxamido)ethyl)piperidine-1-carboxylate

Procedure

The title compound was prepared from 2-oxo-2,3-dihydrooxazole-5-carboxylic acid (step 1) and tert-butyl 4-(2-aminoethyl)piperidine-1-carboxylate analogously to Example 20 step 4;

Sources & evidence

ORD record
ord-db1e01be21b14b8698b4e99d5cff77aa
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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