Methane → Tert-butyl 4-(4-amino-2-methylphenoxy)piperidine-1-carboxylate

HRID 148041Notes

Reaction equation

HRID 148041 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([CH3:24])[cH:17][c:18]([N+:21]([O-:22])=[O:23])[cH:19][cH:20]2)[CH2:12][CH2:13]1.[C:28].[CH3:25][CH2:26][OH:27].[Pd:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([CH3:24])[cH:17][c:18]([NH2:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 297MethaneHCID 702EthanolHCID 23938PalladiumHCID 22181075tert-Butyl 4-(2-methyl-4-nitrophenoxy)piperidine-1-carboxylate

Product 1

HCID 22181171Tert-butyl 4-(4-amino-2-methylphenoxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-681fc8bef23a43848e2634912ea4e03b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…