2-Hydroxy-1,3-oxazole-5-carboxylic acid → 3,5-Dichlorobenzyl 4-(2-(2-oxo-2,3-dihydrooxazole-5-carboxamido)ethyl)piperazine-1-carboxylate

HRID 1480417Notes

Reaction equation

HRID 1480417 reaction equation
[O:1]=[C:2]1[NH:6][CH:5]=[C:4]([C:7]([OH:9])=O)[O:3]1.[NH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[C:27]([Cl:29])[CH:26]=[C:25]([Cl:30])[CH:24]=2)=[O:20])[CH2:15][CH2:14]1>>[O:1]=[C:2]1[NH:6][CH:5]=[C:4]([C:7]([NH:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[C:25]([Cl:30])[CH:24]=3)=[O:20])[CH2:15][CH2:14]2)=[O:9])[O:3]1

Participants

3

Reactant 2

HCID 539814232-Hydroxy-1,3-oxazole-5-carboxylic acidHCID 867226523,5-Dichlorobenzyl 4-(2-aminoethyl)piperazine-1-carboxylate

Product 1

HCID 867226513,5-Dichlorobenzyl 4-(2-(2-oxo-2,3-dihydrooxazole-5-carboxamido)ethyl)piperazine-1-carboxylate

Procedure

The title compound was prepared from 2-oxo-2,3-dihydrooxazole-5-carboxylic acid (Example 21 step 1) and 3,5-dichlorobenzyl 4-(2-aminoethyl)piperazine-1-carboxylate (step 2) analogously to Example 15 step 3;

Sources & evidence

ORD record
ord-a397f7b7e8ea4f9d921a7640c8720826
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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