反应详情

To a stirred solution of (E)-methyl 3-(2,4-dichlorophenyl)acrylate (5052 mg, 21.86 mmol) in THF (109.00 mL) at RT was added 2M NaOH (32.8 mL, 65.6 mmol) and the mixture allowed to stir for 24 hrs. The THF was removed under reduced pressure and on cooling HCl (37%) was added dropwise to the aqueous solution. A solid precipitated out of solution which was filtered and dried to afford the title product;

1. customThe THF was removed under reduced pressure
2. temperatureon cooling HCl (37%)
3. additionwas added dropwise to the aqueous solution
4. customA solid precipitated out of solution which
5. filtrationwas filtered
6. customdried