Hydrochloric Acid → HCID 178520551, compound

HRID 1480453Notes

Reaction equation

HRID 1480453 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([NH:11][CH:12]2[CH2:18][CH:17]3[N:19](C(OC(C)(C)C)=O)[CH:14]([CH2:15][CH2:16]3)[CH2:13]2)=[O:10])[N:3]=[N:2]1.Cl>O1CCOCC1>[CH:17]12[NH:19][CH:14]([CH2:15][CH2:16]1)[CH2:13][CH:12]([NH:11][C:9](=[O:10])[CH2:8][CH2:7][CH2:6][C:4]1[N:3]=[N:2][NH:1][CH:5]=1)[CH2:18]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451399HCID 178451399, compound

Product 1

HCID 178520551HCID 178520551, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A reaction mixture comprising of tert-butyl 3-(4-(1H-1,2,3-triazol-4-yl)butanamido)-8-azabicyclo[3.2.1]octane-8-carboxylate (401 mg, 1.103 mmol) in dioxane (5 ml) was treated with 4M HCl in dioxane (0.827 ml, 3.31 mmol) and stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to afford the title compound. The material was taken on to the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d7caec12b6d143a3a670b2f52e9e7227
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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