Hydrochloric Acid → HCID 86722695, compound

HRID 1480477Notes

Reaction equation

HRID 1480477 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1.[OH-].[Na+].[C:13](Cl)(=[O:24])[O:14][CH2:15][C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([Cl:23])[CH:17]=1.Cl>C(Cl)Cl>[Cl:22][C:20]1[CH:21]=[C:16]([CH:17]=[C:18]([Cl:23])[CH:19]=1)[CH2:15][O:14][C:13]([N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1)=[O:24]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15125944-Piperidineacetic acidHCID 133055323,5-Dichlorobenzyl Chloroformate

Product 1

HCID 86722695HCID 86722695, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 2-(piperidin-4-yl)acetic acid (1 g, 6.98 mmol) in DCM (23 ml) was added 2M NaOH (10.48 ml, 20.95 mmol) and 3,5-dichlorobenzyl carbono-chloridate (1.673 g, 6.98 mmol) to give a white biphasic mixture. After vigorous stirring at RT for 1 hr the reaction mixture was acidified with HCl (6M, 3.49 ml) and then extracted with DCM. The organics were dried with MgSO4, filtered and concentrated under pressure to give the title compound as a colourless oil.

Workup

  1. customto give a white biphasic mixture
  2. extractionextracted with DCM
  3. dry with materialThe organics were dried with MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated under pressure

Sources & evidence

ORD record
ord-a33b12fd38344dedac41867c08c9bed3
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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