HCID 86722713, compound → HCID 178452124, compound

HRID 1480498Notes

Reaction equation

HRID 1480498 reaction equation
C([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:20][CH:21]2[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]2)=[O:19])[N:10]=[N:9]1)C1C=CC=CC=1.[H][H]>C(O)C>[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:20][CH:21]2[CH2:22][CH2:23][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:25][CH2:26]2)=[O:19])[N:10]=[N:9]1

Participants

4

Reactant 2

HCID 86722713HCID 86722713, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 178452124HCID 178452124, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Tert-butyl 4-(6-(1-benzyl-1H-1,2,3-triazol-4-yl)hexanamido)piperidine-1-carboxylate (187 mg, 0.410 mmol) was dissolved in ethanol (10 ml) to give a yellow solution. The solution was then submitted to continuous flow hydrogenation using H-cube hydrogenation apparatus, at 70° C. and 30 bar hydrogen pressure for 2 hours. The resultant solution was concentrated under reduced pressure to yield the title compound.

Workup

  1. customto give a yellow solution
  2. concentrationThe resultant solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e1977b7cd9164f47a8b9bfb598945e3e
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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