Hydrochloric Acid → HCID 178520582, compound

HRID 1480499Notes

Reaction equation

HRID 1480499 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([NH:13][CH:14]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)=[O:12])[N:3]=[N:2]1.Cl>O1CCOCC1>[NH:17]1[CH2:16][CH2:15][CH:14]([NH:13][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:4]2[N:3]=[N:2][NH:1][CH:5]=2)[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452124HCID 178452124, compound

Product 1

HCID 178520582HCID 178520582, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Tert-butyl 4-(6-(1H-1,2,3-triazol-4-yl)hexanamido)piperidine-1-carboxylate (135 mg, 0.369 mmol) in 1,4-dioxane (1.2 ml) was treated with 4M HCl in dioxane (1.8 ml, 7.39 mmol). The reaction mixture was allowed to stir at RT for 3 hours. Concentration yielded the title compound as a hydrochloride salt.

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-d6137dd1a310422c9287b5e308389911
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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