Dimethylformamide → 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(1-methyl-4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 148059Notes

Reaction equation

HRID 148059 reaction equation
[C:37](=[O:38])([O-:39])[O-:40].[CH3:45][N:46]([CH3:47])[CH:48]=[O:49].[Cs+:41].[Cs+:42].[F:1][c:2]1[c:3]([CH2:9][C:10](=[O:11])[N:12]2[CH2:13][CH2:14][c:15]3[cH:16][c:17](-[c:21]4[cH:22][n:23]([CH:31]5[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]5)[c:24]5[n:25][cH:26][n:27][c:28]([NH2:30])[c:29]45)[cH:18][cH:19][c:20]32)[cH:4][c:5]([F:8])[cH:6][cH:7]1.[I:43][CH3:44]>>[F:1][c:2]1[c:3]([CH2:9][C:10](=[O:11])[N:12]2[CH2:13][CH2:14][c:15]3[cH:16][c:17](-[c:21]4[cH:22][n:23]([CH:31]5[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]5)[c:24]5[n:25][cH:26][n:27][c:28]([NH2:30])[c:29]45)[cH:18][cH:19][c:20]32)[cH:4][c:5]([F:8])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 668236445-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Product 1

HCID 668235635-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(1-methyl-4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-3ef628a00948426083f8aa0021f9d1df
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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