2-Chloropyridine-5-boronic acid → 4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-chloropyridin-3-yl)phenol hydrochloride
Reaction equation
Br[C:2]1[C:11]2[O:10]C[N:8]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][C:6]=2[CH:5]=[C:4]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:3]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][N:22]=1>>[ClH:20].[C:16]([C:4]1[CH:3]=[C:2]([C:24]2[CH:23]=[N:22][C:21]([Cl:20])=[CH:26][CH:25]=2)[C:11]([OH:10])=[C:6]([CH2:7][NH:8][C:12]([CH3:13])([CH3:14])[CH3:15])[CH:5]=1)([CH3:17])([CH3:18])[CH3:19]Participants
3
Procedure
The title compound was prepared as a white solid using the procedure described in Example 1 from 8-bromo-3,6-di-tert-butyl-3,4-dihydro-2H-benzo[e][1,3]oxazine (Intermediate 1) and 2-chloropyridine-5-boronic acid [purchased from Frontier Scientific].
Sources & evidence
- ORD record
- ord-477055a73dff4b5c894c8c3234ce4546
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09409893B2
Reaction notes
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