HCID 89996054, compound → HCID 89996101, compound

HRID 1480770Notes

Reaction equation

HRID 1480770 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH:17]=O)=[C:12]([O:19][CH3:20])[CH:11]=2)[CH:7]=[N:6]1.[CH:22]1([NH:28][C:29]2[C:34]3[N:35]=C(S(C)(=O)=O)[N:37]=[CH:38][C:33]=3[CH:32]=[CH:31][N:30]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([NH:28][C:29]2[C:34]3[N:35]=[C:17]([NH:16][C:13]4[CH:14]=[CH:15][C:10]([C:8]5[CH:7]=[N:6][N:5]([CH2:4][CH2:3][N:2]([CH3:21])[CH3:1])[CH:9]=5)=[CH:11][C:12]=4[O:19][CH3:20])[N:37]=[CH:38][C:33]=3[CH:32]=[CH:31][N:30]=2)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 89996054HCID 89996054, compoundHCID 90000823HCID 90000823, compound

Product 1

HCID 89996101HCID 89996101, compoundYield 25%

Procedure

The title compound was prepared according to Example 40 using N-(4-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-2-methoxyphenyl)formamide (Preparation 64) and N-cyclohexyl-2-(methylsulfonyl)pyrido[3,4-d]pyrimidin-8-amine (Preparation 44). The residue was purified by silica gel column chromatography eluting with 0 to 10% MeOH in DCM to give the title compound (26 mg, 25%).

Workup

  1. customThe title compound was prepared
  2. customThe residue was purified by silica gel column chromatography
  3. washeluting with 0 to 10% MeOH in DCM

Sources & evidence

ORD record
ord-313a608a1da44c31a65d6aac6cc3a151
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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