HCID 89996185, compound → HCID 73386776, compound

HRID 1480779Notes

Reaction equation

HRID 1480779 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:10]=[N:11][N:12]([CH3:14])[CH:13]=2)[CH:6]=[CH:5][C:4]=1[NH:15][CH:16]=O.[CH:18]1([CH2:21][O:22][C:23]2[C:28]3[N:29]=C(S(C)(=O)=O)[N:31]=[CH:32][C:27]=3[CH:26]=[CH:25][N:24]=2)[CH2:20][CH2:19]1>>[CH:18]1([CH2:21][O:22][C:23]2[C:28]3[N:29]=[C:16]([NH:15][C:4]4[CH:5]=[CH:6][C:7]([C:9]5[CH:10]=[N:11][N:12]([CH3:14])[CH:13]=5)=[CH:8][C:3]=4[O:2][CH3:1])[N:31]=[CH:32][C:27]=3[CH:26]=[CH:25][N:24]=2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 89996185HCID 89996185, compoundHCID 89996294HCID 89996294, compound

Product 1

HCID 73386776HCID 73386776, compoundYield 52%

Procedure

The title compound was prepared according to Example 40 using N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide (Preparation 56) and 8-(cyclopropylmethoxy)-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine (Preparation 69). The residue was purified by silica gel column chromatography eluting with 0 to 75% EtOAc in cyclohexane to give the title compound (27 mg, 52%).

Workup

  1. customThe title compound was prepared
  2. customThe residue was purified by silica gel column chromatography
  3. washeluting with 0 to 75% EtOAc in cyclohexane

Sources & evidence

ORD record
ord-02649d0911fd4f66ba86d34c5a69f311
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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