Cyclopropanemethanamine → HCID 89996273, compound

HRID 1480787Notes

Reaction equation

HRID 1480787 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=4)=[CH:15][C:14]=3[O:25][CH2:26][CH3:27])[N:10]=[CH:11][C:6]=2[CH:5]=[CH:4][N:3]=1.[CH:28]1([CH2:31][NH2:32])[CH2:30][CH2:29]1>>[CH:28]1([CH2:31][NH:32][C:2]2[C:7]3[N:8]=[C:9]([NH:12][C:13]4[CH:18]=[CH:17][C:16]([C:19]5[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=5)=[CH:15][C:14]=4[O:25][CH2:26][CH3:27])[N:10]=[CH:11][C:6]=3[CH:5]=[CH:4][N:3]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 89996073HCID 89996073, compound

Product 1

HCID 89996273HCID 89996273, compoundYield 5%

Procedure

The title compound was prepared according to the method described for Example 99 using 8-chloro-N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine (Preparation 114) and cyclopropanemethylamine for 5 hours. The residue was further purified by passage through a SCX-2 cartridge eluting with 100% MeOH—0.5 M NH3 in MeOH to give the title compound (2.6 mg, 5%).

Workup

  1. customThe title compound was prepared
  2. customThe residue was further purified by passage through a SCX-2 cartridge
  3. washeluting with 100% MeOH—0.5 M NH3 in MeOH

Sources & evidence

ORD record
ord-a66acf29166b4a39a138cad3fa5ddb30
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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