4-Aminotetrahydropyran → HCID 89996036, compound

HRID 1480788Notes

Reaction equation

HRID 1480788 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=4)=[CH:15][C:14]=3[O:25][CH2:26][CH3:27])[N:10]=[CH:11][C:6]=2[CH:5]=[CH:4][N:3]=1.[NH2:28][CH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[CH2:26]([O:25][C:14]1[CH:15]=[C:16]([C:19]2[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=2)[CH:17]=[CH:18][C:13]=1[NH:12][C:9]1[N:10]=[CH:11][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:28][CH:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)[C:7]=2[N:8]=1)[CH3:27]

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 89996073HCID 89996073, compound

Product 1

HCID 89996036HCID 89996036, compoundYield 9%

Procedure

The title compound was prepared according to the method described for Example 99 using 8-chloro-N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine (Preparation 114) and 4-aminotetrahydropyran. The residue was further purified by passage through a SCX-2 cartridge eluting with 100% MeOH—1M NH3 in MeOH to give the title compound (3 mg, 9%).

Workup

  1. customThe title compound was prepared
  2. customThe residue was further purified by passage through a SCX-2 cartridge
  3. washeluting with 100% MeOH—1M NH3 in MeOH

Sources & evidence

ORD record
ord-a71798a944284b41b8d23272c0d77b26
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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