Formic Acid → HCID 89996299, compound

HRID 1480838Notes

Reaction equation

HRID 1480838 reaction equation
[CH3:1][C:2]1[CH:8]=[C:7]([C:9]2[CH:10]=[N:11][N:12]([CH3:14])[CH:13]=2)[CH:6]=[CH:5][C:3]=1[NH2:4].[CH:15](O)=[O:16]>>[CH3:1][C:2]1[CH:8]=[C:7]([C:9]2[CH:10]=[N:11][N:12]([CH3:14])[CH:13]=2)[CH:6]=[CH:5][C:3]=1[NH:4][CH:15]=[O:16]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 61025921HCID 61025921, compound

Product 1

HCID 89996299HCID 89996299, compound

Procedure

A solution of 2-methyl-4-(1-methyl-1H-pyrazol-4-yl)aniline (Preparation 98, 100 mg, 0.534 mmol) in formic acid (3 mL) was heated to reflux for 3 hours. The reaction mixture was concentrated in vacuo. The residue was partitioned between aqueous saturated NaHCO3 solution (30 mL) and EtOAc (30 mL). The aqueous layer was re-extracted with EtOAc (30 mL).

Workup

  1. temperatureto reflux for 3 hours
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customThe residue was partitioned between aqueous saturated NaHCO3 solution (30 mL) and EtOAc (30 mL)
  4. extractionThe aqueous layer was re-extracted with EtOAc (30 mL)

Sources & evidence

ORD record
ord-7bd3687cf1e34192a1238fd54adb8196
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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