6-Bromo-2-methoxypyridin-3-amine → HCID 89996203, compound

HRID 1480851Notes

Reaction equation

HRID 1480851 reaction equation
Br[C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([NH2:10])=[CH:4][CH:3]=1.[CH3:11][N:12]1[C:16]([CH3:17])=[C:15](B2OC(C)(C)C(C)(C)O2)[CH:14]=[N:13]1>>[CH3:11][N:12]1[C:16]([CH3:17])=[C:15]([C:2]2[N:7]=[C:6]([O:8][CH3:9])[C:5]([NH2:10])=[CH:4][CH:3]=2)[CH:14]=[N:13]1

Participants

3

Reactant 2

HCID 105361376-Bromo-2-methoxypyridin-3-amineHCID 426473131,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 1

HCID 89996203HCID 89996203, compound

Procedure

The title compound was prepared according to the method described for Preparation 158 using 6-bromo-2-methoxypyridin-3-amine and 1,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. The crude residue was purified using silica gel column chromatography eluting with 1-10% MeOH/aqueous ammonia (10/1) in DCM.

Workup

  1. customThe crude residue was purified
  2. washeluting with 1-10% MeOH/aqueous ammonia (10/1) in DCM

Sources & evidence

ORD record
ord-53a46d813acf45dc88af6d24e47f34e3
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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