(3-Methyloxolan-3-yl)methanamine → N-((3-methyltetrahydrofuran-3-yl)methyl)-2-(methylthio)pyrido[3,4-d]pyrimidin-8-amine

HRID 1480856Notes

Reaction equation

HRID 1480856 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([S:12][CH3:13])[N:10]=[CH:11][C:6]=2[CH:5]=[CH:4][N:3]=1.[CH3:14][C:15]1([CH2:20][NH2:21])[CH2:19][CH2:18][O:17][CH2:16]1>>[CH3:14][C:15]1([CH2:20][NH:21][C:2]2[C:7]3[N:8]=[C:9]([S:12][CH3:13])[N:10]=[CH:11][C:6]=3[CH:5]=[CH:4][N:3]=2)[CH2:19][CH2:18][O:17][CH2:16]1

Participants

3

Reactant 2

HCID 54593129(3-Methyloxolan-3-yl)methanamineHCID 899960258-Chloro-2-(methylthio)pyrido[3,4-d]pyrimidine

Product 1

HCID 89996205N-((3-methyltetrahydrofuran-3-yl)methyl)-2-(methylthio)pyrido[3,4-d]pyrimidin-8-amine

Procedure

The title compound was prepared according to the method described for Preparation 175 using of 8-chloro-2-(methylthio)pyrido[3,4-d]pyrimidine (Preparation 33) and (3-methyltetrahydrofuran-3-yl)methanamine at 130° C.

Workup

  1. customdescribed for Preparation 175

Sources & evidence

ORD record
ord-695809c229864192b3373cbec3ba42cf
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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