Ethanol → HCID 89996208, compound

HRID 1480866Notes

Reaction equation

HRID 1480866 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[N:16]([CH3:17])[N:15]=[N:14][N:13]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O.CCO>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[N:16]([CH3:17])[N:15]=[N:14][N:13]=2)[CH:6]=[CH:7][C:8]=1[NH2:9]

Participants

5

Reactant 2

HCID 702EthanolHCID 89996091HCID 89996091, compound

Product 1

HCID 89996208HCID 89996208, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10% Pd on carbon (7 mg, 0.268 mmol) was added to a solution of 5-(3-methoxy-4-nitrophenyl)-1-methyl-1H-tetrazole (Preparation 195, 63 mg, 0.268 mmol) in EtOAc (1.2 mL). The reaction mixture was stirred at room temperature under a hydrogen atmosphere for 1 hour. EtOH (0.5 mL) was added and the reaction mixture was stirred for 1.5 hours. The reaction was filtered and the filtrate concentrated in vacuo to afford the title product as a white solid (52 mg, 95%).

Workup

  1. stirringthe reaction mixture was stirred for 1.5 hours
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-ed77eb5c843f405f9034702aff058298
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

Loading…