4-Morpholinopiperidine → 4-[1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl]morpholine

HRID 1480874Notes

Reaction equation

HRID 1480874 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH2:15][CH2:14]1>>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:13]2[CH2:18][CH2:17][CH:16]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[CH2:15][CH2:14]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 7957244-MorpholinopiperidineHCID 27792505-Fluoro-2-nitroanisole

Product 1

HCID 574161544-[1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl]morpholine

Procedure

The title compound was prepared according to the method described for Preparation 78 using 4-fluoro-2-methoxy-1-nitrobenzene and 4-(piperidin-4-yl)morpholine. The residue was purified using silica gel column chromatography eluting with 80-100% DCM in cyclohexanes.

Workup

  1. customThe residue was purified
  2. washeluting with 80-100% DCM in cyclohexanes

Sources & evidence

ORD record
ord-684b0b21b168427d8842dd17a318efb4
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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