1-(Methylsulfonyl)piperazine → 1-(3-Methoxy-4-nitro-phenyl)-4-methylsulfonyl-piperazine

HRID 1480879Notes

Reaction equation

HRID 1480879 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[CH3:13][S:14]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:16])=[O:15]>>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([S:14]([CH3:13])(=[O:16])=[O:15])[CH2:18][CH2:19]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 27792505-Fluoro-2-nitroanisole

Product 1

HCID 598602551-(3-Methoxy-4-nitro-phenyl)-4-methylsulfonyl-piperazine

Procedure

The title compound was prepared according to the method described for Preparation 78 using 4-fluoro-2-methoxy-1-nitrobenzene and 1-(methylsulfonyl)piperazine for 96 hours. The residue was purified by silica gel column chromatography eluting with 50-100% DCM in cyclohexanes.

Workup

  1. customThe residue was purified by silica gel column chromatography
  2. washeluting with 50-100% DCM in cyclohexanes

Sources & evidence

ORD record
ord-1d5cb459ac8f464a90470f2296702634
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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