Sodium Hydroxide → HCID 57378192, compound

HRID 1480922Notes

Reaction equation

HRID 1480922 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[N:8]=[N:9][N:10]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[NH:20][S:21]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:26][CH:25]=2)(=[O:23])=[O:22])[C:11]=1[CH3:12])=[O:6]>C1COCC1>[C:30]([C:27]1[CH:28]=[CH:29][C:24]([S:21]([NH:20][C:14]2[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=2[N:10]2[C:11]([CH3:12])=[C:7]([C:5]([OH:6])=[O:4])[N:8]=[N:9]2)(=[O:22])=[O:23])=[CH:25][CH:26]=1)([CH3:33])([CH3:31])[CH3:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57378078HCID 57378078, compound

Product 1

HCID 57378192HCID 57378192, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

3 N NaOH (0.1 mL) was added to 1-[2-(4-tert-butyl-benzenesulfonylamino)-5-chloro-phenyl]-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester (synthesized according to general procedure GG, 22 mg, 0.047 mmol) in THF and the resultant reaction mixture stirred at 60° C. overnight. The following day, the reaction mixture was concentrated to dryness and purified by preparative TLC to generate the title compound: MS (ES) M+H expected 449.1, found 449.3.

Workup

  1. customthe resultant reaction mixture
  2. concentrationThe following day, the reaction mixture was concentrated to dryness
  3. custompurified by preparative TLC

Sources & evidence

ORD record
ord-b1deeba4f6c1406a969c78e28c81fabc
Source dataset
uspto-grants-2016_08
Patent number
US09409909B2

Reaction notes

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