2,4-Dichloropyrimidine → 4-(3-Butoxy-phenyl)-2-chloro-pyrimidine

HRID 14811Notes

Reaction equation

HRID 14811 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH2:9]([O:13][C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1)[CH2:10][CH2:11][CH3:12]>>[CH2:9]([O:13][C:14]1[CH:19]=[C:18]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=2)[CH:17]=[CH:16][CH:15]=1)[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 50841013-Butoxyphenylboronic Acid

Product 1

HCID 866032734-(3-Butoxy-phenyl)-2-chloro-pyrimidine

Procedure

2,4 dichloropyrimidine was coupled with 3-butoxyphenylboronic acid following procedure A. LC-MS showed the product had the expected M+H+ of 263.

Sources & evidence

ORD record
ord-81787f2a93114da293830fbcc297134d
Source dataset
uspto-grants-2010_06
Patent number
US07732444B2

Reaction notes

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