3-Chloro-2,6-difluorobenzaldehyde → 1-(3-Chloro-2-fluoro-6-methoxyphenyl)prop-2-en-1-one

HRID 1481262Notes

Reaction equation

HRID 1481262 reaction equation
Cl[C:2]1C(F)=C(C(F)=C[CH:9]=1)C=O.[Cl:12][C:13]1[C:14]([F:23])=[C:15]([C:18]([O:21][CH3:22])=[CH:19][CH:20]=1)[CH:16]=[O:17]>>[Cl:12][C:13]1[C:14]([F:23])=[C:15]([C:16](=[O:17])[CH:2]=[CH2:9])[C:18]([O:21][CH3:22])=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 7363383-Chloro-2,6-difluorobenzaldehydeHCID 221397073-Chloro-2-fluoro-6-methoxybenzaldehyde

Product 1

HCID 900344571-(3-Chloro-2-fluoro-6-methoxyphenyl)prop-2-en-1-one

Procedure

1-(3-Chloro-2-fluoro-6-methoxyphenyl)prop-2-en-1-one was prepared using a procedure analogous to intermediate 1 except that 3-chloro-2,6-difluorobenzaldehyde was replaced with 3-chloro-2-fluoro-6-methoxybenzaldehyde. 1H NMR (400 MHz, CHLOROFORM-d) δ 7.43-7.36 (m, 1H), 6.75-6.56 (m, 2H), 6.13-6.03 (m, 2H), 3.80 (s, 3H).

Sources & evidence

ORD record
ord-b526583e79d246a9bb36b07b5b8b77a3
Source dataset
uspto-grants-2016_08
Patent number
US09409908B2

Reaction notes

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