反应详情

To a suspension of furo[2,3-b]pyridine-3-carboxylic acid methyl ester (48 mmol) in 180 mL MeOH was added NaOAc (97 mmol). The flask was evacuated and filled three times with argon, 20% wet Pd(OH)2 on carbon (1000 mg) was added and the reaction was stirred for 20 h under a hydrogen atmosphere. It was then filtered over a 2 cm pad of celite and was washed with EtOH (50 mL) and EtOAc (50 mL). The filtrate was concentrated in vacuo to afford the desired compound as colorless oil.

1. customThe flask was evacuated
2. additionfilled three times with argon, 20% wet Pd(OH)2 on carbon (1000 mg)
3. additionwas added
4. filtrationIt was then filtered over a 2 cm pad of celite
5. washwas washed with EtOH (50 mL) and EtOAc (50 mL)
6. concentrationThe filtrate was concentrated in vacuo