O-Methylhydroxylamine hydrochloride → HCID 131736105, compound

HRID 1481346Notes

Reaction equation

HRID 1481346 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([Cl:11])[CH:10]=1)[C:7](=O)[CH2:6][CH2:5]2.Cl.[CH3:14][O:15][NH2:16]>CO.O>[CH3:14][O:15][N:16]=[C:7]1[C:8]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:10][C:9]=2[Cl:11])[CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 222923465,7-Dichloro-2,3-dihydro-1H-inden-1-one

Product 1

HCID 131736105HCID 131736105, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 5,7-dichloro-1-indanone (0.34 mmol) in 2 mL MeOH was added O-methylhydroxylamine HCl (0.34 mmol). The reaction mixture was stirred at RT for 17 h and then heated to 50° C. for 24 h. The mixture was cooled to RT, diluted with water and extracted 3 times with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as white solid.

Workup

  1. temperatureheated to 50° C. for 24 h
  2. temperatureThe mixture was cooled to RT
  3. extractionextracted 3 times with EtOAc
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-075f523bf57244369eb4c8fbd19d4377
Source dataset
uspto-grants-2016_08
Patent number
US09409917B2

Reaction notes

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