反应详情

温度

60 °C

A solution of BH3 (0.6 mL, 1M in THF) was added to a solution of 5,7-dichloro-2,3-dihydro-1H-inden-1-one O-methyl oxime (0.31 mmol) in 1 mL THF. The reaction mixture was heated to 60° C. for 3 days. An aq. 1M NaOH solution was added and heating to 60° C. was continued for another 24 h. The solvent was removed under vacuo, the residue was diluted with a sat. aq. NaHCO3 solution and extracted 3 times with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as colorless oil.

1. temperatureheating to 60° C.
2. customThe solvent was removed under vacuo
3. additionthe residue was diluted with a sat. aq. NaHCO3 solution
4. extractionextracted 3 times with EtOAc
5. dry with materialThe combined organic layers were dried over MgSO4
6. concentrationconcentrated in vacuo