反应详情

温度

60 °C

A solution of BH3 (1.46 mL, 1M in THF) was added to a solution of 2-((3,5-dichloro-2-cyanobenzyl)oxy)ethyl acetate (0.36 mmol) in 1.5 mL MeOH. The reaction mixture was heated to 60° C. for 3 h. At 0° C., 1.5 mL MeOH was dropwise added and the mixture was stirred until gaz evolution was finished. An aq. solution of 10% NaOH was added still under cooling. The solvent was removed under vacuo, the residue was diluted with water and extracted 3 times with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as yellow solid.

1. temperatureunder cooling
2. customThe solvent was removed under vacuo
3. additionthe residue was diluted with water
4. extractionextracted 3 times with EtOAc
5. dry with materialThe combined organic layers were dried over MgSO4
6. concentrationconcentrated in vacuo