Morpholine → 2-(6-Methylpyridin-3-yl)-2-morpholinoethan-1-amine

HRID 1481355Notes

Reaction equation

HRID 1481355 reaction equation
FC1(F)CC[N:5](C(C2C=CC(C(F)(F)F)=CC=2)CN)[CH2:4]C1.[CH3:22][C:23]1[N:28]=[CH:27][C:26]([CH:29]=O)=[CH:25][CH:24]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1>>[CH3:22][C:23]1[N:28]=[CH:27][C:26]([CH:29]([N:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[CH2:4][NH2:5])=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 101925666-Methyl-3-pyridinecarboxaldehydeHCID 897046912-(4,4-Difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamine

Product 1

HCID 897048472-(6-Methylpyridin-3-yl)-2-morpholinoethan-1-amine

Procedure

This compound was prepared using a method analogous to that of 2-(4,4-difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamine (A.2.18), 6-methyl-pyridine-3-carboxaldehyde replacing 4-(trifluoromethyl)benzaldehyde and morpholine replacing 4,4-difluoropiperidine HCl.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b666b096bc1e4d2790a11f89b73e0a5d
Source dataset
uspto-grants-2016_08
Patent number
US09409917B2

Reaction notes

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