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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1481355Generated: October 31, 2026

Morpholine → 2-(6-Methylpyridin-3-yl)-2-morpholinoethan-1-amine

https://huagongshe.com/reaction/1481355

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant6-Methyl-3-pyridinecarboxaldehydeHCID 10192566—
Reactant2-(4,4-Difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamineHCID 89704691—
Product2-(6-Methylpyridin-3-yl)-2-morpholinoethan-1-amineHCID 89704847—

Reaction Steps

This compound was prepared using a method analogous to that of 2-(4,4-difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamine (A.2.18), 6-methyl-pyridine-3-carboxaldehyde replacing 4-(trifluoromethyl)benzaldehyde and morpholine replacing 4,4-difluoropiperidine HCl.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09409917B2
Source datasetuspto-grants-2016_08
ORD IDord-b666b096bc1e4d2790a11f89b73e0a5d
Source noteuspto-grants-2016_08