Morpholine → 2-(2-Cyclopropylpyrimidin-5-yl)-2-morpholinoethanamine

HRID 1481356Notes

Reaction equation

HRID 1481356 reaction equation
FC1(F)[CH2:7][CH2:6][N:5]([CH:8]([C:11]2[CH:16]=CC(C(F)(F)F)=C[CH:12]=2)[CH2:9][NH2:10])[CH2:4][CH2:3]1.[CH:22]1([C:25]2[N:30]=CC(C=O)=C[N:26]=2)[CH2:24][CH2:23]1.N1CC[O:36]CC1>>[CH:22]1([C:25]2[N:30]=[CH:12][C:11]([CH:8]([N:5]3[CH2:4][CH2:3][O:36][CH2:7][CH2:6]3)[CH2:9][NH2:10])=[CH:16][N:26]=2)[CH2:24][CH2:23]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 249036232-Cyclopropylpyrimidine-5-carbaldehydeHCID 897046912-(4,4-Difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamine

Product 1

HCID 897047072-(2-Cyclopropylpyrimidin-5-yl)-2-morpholinoethanamine

Procedure

This compound was prepared using a method analogous to that of 2-(4,4-difluoropiperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)-ethanamine (A.2.18), 2-cyclopropylpyrimidine-5-carbaldehyde replacing 4-(trifluoromethyl)benzaldehyde and morpholine replacing 4,4-difluoropiperidine HCl.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-2a8d99e46ef64b2786a02d1b470293a6
Source dataset
uspto-grants-2016_08
Patent number
US09409917B2

Reaction notes

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