Hydrochloric Acid → HCID 89704802, compound

HRID 1481364Notes

Reaction equation

HRID 1481364 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([Cl:11])[CH:10]=1)[C:7](=[O:12])[C:6](=[N:13]O)[CH2:5]2.Cl>CCO.[Pd]>[NH2:13][CH:6]1[CH2:5][C:4]2[C:8](=[C:9]([Cl:11])[CH:10]=[C:2]([Cl:1])[CH:3]=2)[C:7]1=[O:12]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131736639HCID 131736639, compound

Product 1

HCID 89704802HCID 89704802, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 5,7-dichloro-2-(hydroxyimino)-2,3-dihydro-1H-inden-1-one (0.56 mmol) in 4 mL EtOH were added Pd on carbon (5 mg) and 0.1 mL 25% HCl solution. The mixture was stirred overnight under a hydrogen atmosphere. It was then filtered over a 2 cm pad of celite and washed with EtOH (20 mL) and EtOAc (20 mL). The filtrate was concentrated in vacuo to give the desired product as brown oil.

Workup

  1. filtrationIt was then filtered over a 2 cm pad of celite
  2. washwashed with EtOH (20 mL) and EtOAc (20 mL)
  3. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-fba11749669c4d958487cc1b78dda4c9
Source dataset
uspto-grants-2016_08
Patent number
US09409917B2

Reaction notes

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