Acetone hexane → HCID 90011170, compound

HRID 1481487Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][C:10]([C:17]([NH:19][N:20]=[C:21]([CH3:23])[CH3:22])=[O:18])=[N:9]2)=[N:6][CH:7]=1.[CH3:24][C:25](C)=[O:26].CCCCCC>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]([F:16])([F:14])[F:15])=[CH:11][C:10]([C:17]3[O:18][C:21]([CH3:23])([CH3:22])[N:20]([C:25](=[O:26])[CH3:24])[N:19]=3)=[N:9]2)=[N:6][CH:7]=1

Participants

Reactant 2

HCID 21880519Acetone hexane

HCID 90011544HCID 90011544, compound

Product 1

HCID 90011170HCID 90011170, compoundYield 72%

Procedure

Step-2: 1-(5-Bromopyridin-2-yl)-N′-(propan-2-ylidene)-5-(trifluoromethyl)-1H-pyrazole-3-carbohydrazide: A solution of step-1 intermediate (1.0 g, 2.86 mmol) in acetone: hexane (1:1, 12 mL) was stirred at 70° C. for 3 h. The reaction was then cooled to room temperature and the solvent was evaporated under vacuum to afford 800 mg (72%) of the title compound as white solid. ESI-MS (m/z) 390, 392 [(MH)+, Br79,81].

Workup

customthe solvent was evaporated under vacuum

Sources & evidence

ORD record: ord-1096c745e5c0495da01660c87f0478f3
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409898B2

Reaction notes

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