HCID 90011425, compound → HCID 90011543, compound

HRID 1481494Notes

Reaction equation

HRID 1481494 reaction equation
[CH3:1][N:2]1[N:6]=[C:5]([C:7]2[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[N:9]([C:16]3[CH:17]=[N:18][C:19]([N+:22]([O-])=O)=[CH:20][CH:21]=3)[N:8]=2)[O:4][C:3]1=[O:25]>C(#N)C>[NH2:22][C:19]1[N:18]=[CH:17][C:16]([N:9]2[C:10]([C:12]([F:14])([F:13])[F:15])=[CH:11][C:7]([C:5]3[O:4][C:3](=[O:25])[N:2]([CH3:1])[N:6]=3)=[N:8]2)=[CH:21][CH:20]=1

Participants

3

Reactant 1

HCID 90011425HCID 90011425, compound

Product 1

HCID 90011543HCID 90011543, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Step-6: 3-Methyl-5-(1-(6-nitropyridin-3-yl)-5-(trifluoromethyl)-1H-pyrazol-3-yl)-1,3,4-oxadiazol-2(3H)-one: The title compound was prepared from step-5 intermediate by following the similar procedure sequentially as described in Step-5 and Step-6 of Intermediate-1. 1HNMR (400 MHz, CDCl3) δ 8.91(d, J=2.5 Hz, 1H), 8.48 (d, J=8.5 Hz, 1H), 8.31(dd, J=2.5 & 8.5 Hz, 1H), 7.37 (s, 1H), 3.53 (s, 3H); ESI-MS (m/z) 398 (M+acetonitrile).

Sources & evidence

ORD record
ord-d7da622130b34a62bd3af45c6e8f87b7
Source dataset
uspto-grants-2016_08
Patent number
US09409898B2

Reaction notes

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