HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-iodoaniline → (R)-tert-butyl 2-((2-amino-5-bromophenyl)ethynyl)pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-iodoaniline | HCID 823934 | — |
| Reactant | tert-butyl (2R)-2-ethynylpyrrolidine-1-carboxylate | HCID 10262067 | — |
| Product | (R)-tert-butyl 2-((2-amino-5-bromophenyl)ethynyl)pyrrolidine-1-carboxylate | HCID 117844394 | 89% |
Reaction Steps
(R)-tert-butyl 2-((2-amino-5-bromophenyl)ethynyl)pyrrolidine-1-carboxylate (4.32 g) was prepared via Sonogashira coupling according to the general procedure described in Example 156, Step 1, from 4-bromo-2-iodoaniline (3.96 g, 13.29 mmol) and (R)-tert-butyl 2-ethynylpyrrolidine-1-carboxylate (3.25 g, 16.64 mmol) in 89% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409905B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-9b531b4ab72449d4ba7b244d3ab0981a |
| Source note | uspto-grants-2016_08 |