反应详情

Following the procedure of Example 375 step 7, treatment of tert-butyl 2,4-di-tert-butoxy-5-chloro-6-(1-methyl-1H-indol-5-yl)nicotinate (27 mg, 0.055 mmol) with HCl in dioxane (4.0 M×1.0 mL, 4.0 mmol) provided 5-chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (12 mg, 68%).