反应详情

The intermediate obtained in Step 4 (170 mg, 0.24 mmol) was dissolved in a mixed solvent of MeOH (0.5 mL) and ethyl acetate (2.0 mL) and hydrogenated with 10% Pd on charcoal (50 mg) using a balloon at room temperature. LC/MS showed complete conversion was achieved overnight. The catalyst was filtered over Celite and washed with 5% MeOH in DCM. The filtrate was concentrated to dryness and the residue was triturated with DCM and dried to provide the title compound as a pale yellow powder (27 mg) in 34% yield.

1. customat room temperature
2. filtrationThe catalyst was filtered over Celite
3. washwashed with 5% MeOH in DCM
4. concentrationThe filtrate was concentrated to dryness
5. customthe residue was triturated with DCM
6. customdried