反应详情

Prepared in 88% yield from 2-bromo-4-(trifluoromethoxy)phenol following the same procedure as (S)-1-bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene. 1H NMR (400 MHz, CDCl3) δ 7.45 (d, J=2.3 Hz, 1H), 7.13 (dd, J=8.9, 2.1 Hz, 1H), 6.90 (d, J=9.0 Hz, 1H), 5.90 (ddt, J=17.2, 10.1, 7.1 Hz, 1H), 5.22-5.09 (m, 2H), 4.50-4.35 (m, 1H), 2.63-2.48 (m, 1H), 2.48-2.36 (m, 1H), 1.37 (d, J=6.0 Hz, 3H).