HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-(trifluoromethoxy)phenol → (S)-2-Bromo-1-(pent-4-en-2-yloxy)-4-(trifluoromethoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-(trifluoromethoxy)phenol | HCID 21584090 | — |
| Reactant | (S)-1-Bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene | HCID 118308806 | — |
| Product | (S)-2-Bromo-1-(pent-4-en-2-yloxy)-4-(trifluoromethoxy)benzene | HCID 118308885 | 88% |
Reaction Steps
Prepared in 88% yield from 2-bromo-4-(trifluoromethoxy)phenol following the same procedure as (S)-1-bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene. 1H NMR (400 MHz, CDCl3) δ 7.45 (d, J=2.3 Hz, 1H), 7.13 (dd, J=8.9, 2.1 Hz, 1H), 6.90 (d, J=9.0 Hz, 1H), 5.90 (ddt, J=17.2, 10.1, 7.1 Hz, 1H), 5.22-5.09 (m, 2H), 4.50-4.35 (m, 1H), 2.63-2.48 (m, 1H), 2.48-2.36 (m, 1H), 1.37 (d, J=6.0 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409922B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-132b7085941b4992b57730100aca667d |
| Source note | uspto-grants-2016_08 |