Sodium borohydride → Methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-5-(hydroxymethyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate

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Methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-5-formyl-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate (15 mg, 0.022 mmol, 1.0 equiv) was dissolved in MeOH (437 μl). To this solution was added sodium borohydride (3.31 mg, 0.087 mmol, 4.0 equiv) and stirred at r.t. The solution turned to colorless immediately. It was stirred for ten minutes and quenched by water, extracted by Ethyl Acetate. The organic layer was concentrated to give the pure enough product for the next reaction.

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