反应详情

1-(4-chlorobutyl)-1H-benzimidazole (7.51 g, 0.036 mol) was dissolved into 100 ml of acetonitrile, 4-(2-pyrimidinyl) piperazine (4.9 g, 0.03 mol), diisopropylethylamine (15.5 g, 0.12 mol) and potassium iodide (5.0 g, 0.03 mol) were respectively added. The mixture was stirred for 10 min at ambient temperature, and then heated and refluxed to react for 20 hours. The mixture was cooled down to ambient temperature and filtered. The filtrate was concentrated to produce oily products, and treated by chromatography with neutral Al2O3, eluted with dichloromethane/methanol mixture to produce 6.1 g compound (I-14) with a yield of 60.1%. ESI-MS [M+H]+: m/z 337.2.

1. additionwere respectively added
2. temperatureheated
3. temperaturerefluxed
4. customto react for 20 hours
5. temperatureThe mixture was cooled down to ambient temperature
6. filtrationfiltered
7. concentrationThe filtrate was concentrated
8. customto produce oily products
9. additiontreated by chromatography with neutral Al2O3
10. washeluted with dichloromethane/methanol mixture