反应详情

1-(3-chloropropyl)-1H-benzotriazole (11.7 g, 0.06 mol) was dissolved into 150 ml of acetonitrile, 3-(piperidine-4-yl)benzisoxazole (10.1 g, 0.05 mol), diisopropylethylamine (25.8 g, 0.02 mol) and potassium iodide (8.3 g, 0.05 mol) were respectively added. The mixture was stirred and mixed, then heated and refluxed to react for 15 hours. The mixture was cooled down to ambient temperature and filtered. The filtrate was concentrated to produce oily products, and treated by chromatography with neutral Al2O3 and purified, eluted with dichloromethane to produce 12.6 g compound (I-84) with a yield of 69.7%. ESI-MS [M+H]+: m/z 362.2.

1. additionwere respectively added
2. additionmixed
3. temperatureheated
4. temperaturerefluxed
5. customto react for 15 hours
6. filtrationfiltered
7. concentrationThe filtrate was concentrated
8. customto produce oily products
9. additiontreated by chromatography with neutral Al2O3
10. custompurified
11. washeluted with dichloromethane