HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1482627Generated: November 3, 2026
Sodium Hydroxide → 1-(3-chlorobutyl)-6-cyano-1H-benzotriazole
https://huagongshe.com/reaction/1482627
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 22644751 | HCID 22644751 | — |
| Reactant | 1H-1,2,3-benzotriazole-5-carbonitrile | HCID 178509537 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Product | 1-(3-chlorobutyl)-6-cyano-1H-benzotriazole | HCID 118386845 | 38.8% |
Reaction Steps
6-cyano-1H-benzotriazole (15.9 g, 0.10 mol) is dissolved into 100 ml of 30% wt. sodium hydroxide, 3-chlorobromobutane (32.6 g, 0.10 mol), tetrabutyl ammonium bromide (0.8 g) are added, and mixed for 5 min. The reaction solution is gradually heated to 60° C., stirred for reaction for 2 hours. Post treatment was performed based on common method one for synthesis. The solution was separated and purified by HPLC to produce 9.1 g of 1-(3-chlorobutyl)-6-cyano-1H-benzotriazole, with a yield of 32.6%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09415047B2 |
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| Source dataset | uspto-grants-2016_08 |
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| ORD ID | ord-fbccd650a74e4663bf58fc3d70d245b6 |
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| Source note | uspto-grants-2016_08 |
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