反应详情

温度

60 °C

6-cyano-1H-benzotriazole (15.9 g, 0.10 mol) is dissolved into 100 ml of 30% wt. sodium hydroxide, 3-chlorobromobutane (32.6 g, 0.10 mol), tetrabutyl ammonium bromide (0.8 g) are added, and mixed for 5 min. The reaction solution is gradually heated to 60° C., stirred for reaction for 2 hours. Post treatment was performed based on common method one for synthesis. The solution was separated and purified by HPLC to produce 9.1 g of 1-(3-chlorobutyl)-6-cyano-1H-benzotriazole, with a yield of 32.6%.

1. additionare added
2. additionmixed for 5 min
3. customPost treatment was performed based on common method one for synthesis
4. customThe solution was separated
5. custompurified by HPLC